structural formula

business number	014s
molecular formula	c8h11no3
molecular weight	169.18
label	norepinephrine, (r)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, (r)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, l-arterenol, l-noradrenaline, levarterenol

• numbering system
• physical property data
• toxicological data
• ecological data
• molecular structure data
• computing chemical data
• more
  • properties and stability
  • storage method
  • synthesis method
  • purpose

numbering system

cas number:51-41-2

mdl number:mfcd00025592

einecs number:200-096-6

rtecs number:dn5950000

brn number:2804840

pubchem number:24891196

physical property data

1. properties: off-white to brown fine crystals. sensitive to light and air.

2. density (g/ml, 25/4℃): undetermined

3. relative vapor density (g/ml, air=1): undetermined

4. melting point (ºc): 216.5～218℃ (decomposition)

5. boiling point (ºc, normal pressure): undetermined

6. boiling point (ºc, 5.2kpa): not determined

7. refractive index: not determined

8. flash point (ºc): not determined

9. specific rotation ( º): [α]_d²⁵ -37.3° (c=5, in 1mol/l hydrochloric acid)

10. autoignition point or ignition temperature (ºc): undetermined

11. vapor pressure (kpa, 25ºc): undetermined

12. saturated vapor pressure (kpa, 60ºc): undetermined

13. heat of combustion (kj/mol): undetermined

14. critical temperature (ºc): undetermined

15. critical pressure (kpa): undetermined

16. the logarithmic value of the oil-water (octanol/water) partition coefficient: undetermined

17. the upper limit of explosion (%, v/v): undetermined

18. lower explosion limit (%, v/v): undetermined

19. solubility: soluble in inorganic acids and alkali, slightly soluble in water, methanol, ethanol and ether.

toxicological data

none

ecological data

none

molecular structure data

1. molar refractive index: 44.63

2. molar volume (cm³/mol): 121.0

3. isotonic specific volume (90.2k ): 358.3

4. surface tension (dyne/cm): 76.7

5. polarizability (10-24cm3): 17.69

compute chemical data

1. reference value for hydrophobic parameter calculation (xlogp): none

2. number of hydrogen bond donors: 4

3. number of hydrogen bond acceptors:4

4. number of rotatable chemical bonds: 2

5. number of tautomers: 10

6. topological molecule polar surface area 86.7

p>

7. number of heavy atoms: 12

8. surface charge: 0

9. complexity: 142

10. number of isotope atoms :0

11. determine the number of atomic stereocenters: 1

12. uncertain number of atomic stereocenters: 0

13. determine the chemical bond configuration number of centers: 0

14. number of uncertain chemical bond stereocenters: 0

15. number of covalent bond units: 1

properties and stability

none

storage method

seal with argon and store at 4℃ to avoid light.

synthesis method

it can be made from catechol and chloroacetyl chloride to 3,4-dihydroxy-2-chloroacetophenone, and then reacted with ammonia or methenamine.

purpose

anti-shock vasoactive drugs. it is mainly used to rescue acute hypotension and shock caused by peripheral vasodilation.

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