structural formula
| business number | 016c |
|---|---|
| molecular formula | c12h11cln2o5s |
| molecular weight | 330.74 |
| label |
furosemide, diuretic, furaniline, sulfonamide, abdominal acidity, 4-chloro-n-furfuryl-5-sulfamoylanthranilic acid, 5-(aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid |
numbering system
cas number:54-31-9
mdl number:mfcd00010549
einecs number:200-203-6
rtecs number:cb2625000
brn number:none
pubchem number:24277714
physical property data
1. character:white or off-white crystalline powder, odorless, almost tasteless.
2. density (g/ml,25/4℃): undetermined
3. relative vapor density (g/ml,air=1): undetermined
4. melting point (ºc): 206
5. boiling point (ºc,normal pressure): undetermined
6. boiling point (ºc,5.2kpa): undetermined
7. refractive index: undetermined
8. flashpoint (ºc): undetermined
9. specific optical rotation (º): undetermined
10. autoignition point or ignition temperature (ºc): undetermined
11. vapor pressure (kpa,25ºc): undetermined
12. saturated vapor pressure (kpa,60ºc): undetermined
13. heat of combustion (kj/mol): undetermined
14. critical temperature (ºc): undetermined
15. critical pressure (kpa): undetermined
16. oil and water (octanol/log value of partition coefficient for water: undetermined
17. explosion limit (%,v/v): undetermined
18. lower explosion limit (%,v/v): undetermined
19. solubility:soluble in acetone, methanol, dimethylformamide, slightly soluble in ethanol, insoluble in water
toxicological data
none
ecological data
none
molecular structure data
1. molar refractive index: 75.76
2. molar volume (m3/mol ): 205.8
3. isotonic specific volume (90.2k):606.2
4. surface tension (dyne/cm):75.2
5. polarizability（10-24cm3):30.03
compute chemical data
1. reference value for hydrophobic parameter calculation (xlogp): none
2. number of hydrogen bond donors: 3
3. number of hydrogen bond acceptors: 7
4. number of rotatable chemical bonds: 5
5. number of tautomers: 4
6. topological molecule polar surface area 131
7. number of heavy atoms: 21
8. surface charge: 0
9. complexity: 481
10. number of isotope atoms: 0
11. determine the number of atomic stereocenters: 0
12. uncertain number of atomic stereocenters: 0
13. determine the number of chemical bond stereocenters: 0
14. number of uncertain chemical bond stereocenters: 0
15. number of covalent bond units: 1
properties and stability
none
storage method
this product should be sealed and stored in a cool, dry place.
synthesis method
from 2, 4-dichlorobenzoic acid (see 12740) through chlorosulfonation, ammoniation and acidification to obtain 2, 4-dichloro-5-sulfamoyl benzoic acid is then condensed with furfurylamine to produce furosemide.
purpose
this product has a strong but short-lived diuretic effect. it is a powerful diuretic and is used to treat edema caused by heart, liver, kidney and other diseases. , especially in cases where base diuretics are ineffective; it can be used to treat acute pulmonary edema, cerebral edema, acute renal failure, hypertension and other diseases; combined with rehydration, this product can promote the non-excretion of poisons.
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